LUNAR can target multiple different clinically important cells including stellate cells, hepatocytes, lung epithelial cells, eye cells, and myocytes. The study is being conducted with CTI Clinical Trial and Consulting Services, a global CRO, and in collaboration with Duke-NUS Medical School in Singapore. Unlike other lipid-mediated delivery systems, LUNAR can deliver nucleic acids to a range of clinically important cells and tissues. Forward Looking StatementsThis press release contains forward-looking statements that involve substantial risks and uncertainties for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. Source: Arcturus Therapeutics Holdings Inc. Search There is clearly a need for improved delivery vehicles before RNA medical therapies can become mainstream. Naked nucleic acids can cause a strong immune response and are quickly degraded by enzymes in the bloodstream and the gut. Le solide coffre permet non seulement de bien garder l´appareil mais aussi d´amener le télescope sans grande difficulté là où vous voulez. Viral vectors may cause accidental mutations in host DNA, which can lead to cancer. Arcturus’ commitment to the development of novel RNA therapeutics has led to collaborations with Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., Takeda Pharmaceutical Company Limited, CureVac AG, Synthetic Genomics Inc., Duke-NUS, and the Cystic Fibrosis Foundation. The astronauts will be transferred, then the descent to the lunar surface will follow. :thumbup: ---------- Post added 08-10-12 at 10:34 AM ---------- Previous post was 08-09-12 at 03:56 PM ----------. Are you sure? http://www.orbithangar.com/search_quick.php?text=antares&submit.x=0&submit.y=0. The cell then uses the RNA or DNA medicine to address the disease-causing genetic defect and to produce normal, healthy protein. Nice! A Mars lander is not in our mind at the moment. Any statements, other than statements of historical fact included in this press release, including those regarding the likelihood of success, efficacy or safety of ARCT-021 as a vaccine against COVID-19 and therapeutic potential thereof based on the Company’s mRNA therapeutics, the timing of the release of ARCT-021 clinical data for human trials of a vaccine against COVID-19, the likelihood that ARCT-021 preclinical data will be predictive of clinical data, the expected dose size and required number of doses of ARCT-021 that may be approved for use by any applicable regulatory authority and the impact of general business and economic conditions are forward-looking statements. To address these delivery problems and to improve the safety and tolerance of RNA and DNA medicines, we have developed a novel lipid-mediated delivery system called Lipid-enabled and Unlocked Nucleomonomer Agent modified RNA (LUNAR). SAN DIEGO, Aug. 11, 2020 (GLOBE NEWSWIRE) -- Arcturus Therapeutics Holdings Inc. (the “Company”, “Arcturus”, Nasdaq: ARCT), a leading clinical-stage messenger RNA medicines company focused on the development of infectious disease vaccines and significant opportunities within liver and respiratory rare diseases, today announced that all subjects in the first cohort have been dosed in the Phase 1/2 clinical study with its ARCT-021 investigational vaccine for COVID-19. LUNAR lipids can be used to deliver very small RNAs such as siRNAs and microRNAs and also larger mRNAs and gene editing technologies such as CRISPR and TALENs. “We look forward to sharing initial clinical data from this Phase 1/2 study in Q4 which we expect to enable dose selection for late phase clinical trials.”. “We are very pleased to have initiated dosing in our ARCT-021 Phase 1/2 study, and in fact, we have already completed dosing of all subjects in the first cohort of the study. Directly originating from the Antares capsule, Arcturus is designed to perform unmanned launches aboard the Quasar 452 Super-Heavy class launcher, targeting a lunar parking orbit. In Phase 1, escalating doses will be administered as a single injection to younger adults aged 21 to 55 years old. Here some screenshots about last project development. Submit, Arcturus Therapeutics Announces that it has Initiated Dosing of its COVID-19 STARR™ mRNA Vaccine Candidate, LUNAR-COV19 (ARCT-021) in a Phase 1/2 study. Such statements are based on management’s current expectations and involve risks and uncertainties, including those discussed under the heading "Risk Factors" in Arcturus’ Annual Report on Form 10-K for the fiscal year ended December 31, 2019, filed with the SEC on March 16, 2020 and in subsequent filings with, or submissions to, the SEC. Upon entering the cytosol, the LUNAR … This is the reason why the vehicle is so big. Patients treated with viral vectors can also develop antibodies against these vectors that make the treatment less effective over time. Once release of the RNA into the cytosol occurs, the normal translational machinery of the cell can interact with the RNA to make functional protein that delivers a therapeutic effect. Later in the mission, a manned Antares LR vehicle will rendez-vous with it in lunar orbit. ARCT-021 utilizes Arcturus’ self-transcribing and replicating (STARR™) mRNA technology and is delivered with Arcturus’s proprietary LUNAR® lipid-mediated delivery system. The ARCT-021 vaccine candidate is devoid of viruses and does not utilize viral vectors or adjuvants. Viral vectors and lipid-mediated delivery systems are the two main approaches used in RNA therapeutic development. For a better experience, please enable JavaScript in your browser before proceeding. LUNAR works by encapsulating therapeutic nucleic acids and safely delivering them to target cells through a process called endocytosis. You must log in or register to reply here. Viral vectors and existing lipid vector technology can cause liver damage and activate an adverse immune response in human patients. Arcturus Therapeutics' primary technology platform for RNA therapeutics is called LUNAR® a novel Lipid-enabled nanoparticle. Except as otherwise required by law, Arcturus disclaims any intention or obligation to update or revise any forward-looking statements, which speak only as of the date they were made, whether as a result of new information, future events or circumstances or otherwise. ARCT-021 preclinical data has shown highly promising results with 100% seroconversion for neutralizing antibodies after a single administration using a very low 2 µg dose. Dag_The_Pimple 4. Therefore, RNA and DNA medicines must be delivered to target cells using a vector. LUNAR is a multi-component drug delivery system that enables scientists to target specific cells inside the body and deliver a payload of RNA into the cells cytosol. LUNAR ® particles associate with the cell membrane of a target cell of interest and quickly enter the cell via endocytosis. Arcturus’ technologies are covered by its extensive patent portfolio (192 patents and patent applications, issued in the U.S., Europe, Japan, China and other countries). The ascent module is designed both for lunar surface - lunar orbit taxi service and 2 weeks stay. Neutralizing antibodies continued to increase for 60 days after dosing. LUNAR can target multiple different clinically important cells including stellate cells, hepatocytes, lung epithelial cells, eye cells, and myocytes. JavaScript is disabled. Arcturus is combining its self-replicating mRNA STARR™ Technology with their LUNAR® RNA medicine delivery technology to developing a prophylactic vaccine against influenza. LUNAR delivery technology can be used with multiple types of nucleic acid therapeutics. Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, replicon RNA, antisense RNA, microRNA, DNA, and gene editing therapeutics. The ARCT-021 Phase 1/2 study includes two parts. This means we only need to deliver a small amount of the active pharmaceutical ingredient in order to see therapeutic effects, and so are able to avoid adverse events and side effects. Are you sure? Based upon the safety, immunogenicity and T-cell response data from this group, dose regimens will be selected for further evaluation in Phase 2 which includes cohorts in younger adults and older adults aged 56 to 80 years old. Arcturus may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in any forward-looking statements such as the foregoing and you should not place undue reliance on such forward-looking statements.

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